CAR-cell therapies in rheumatic disease · corrected evidence explorer

CAR-Cell Reality Check

153 individually attributable records in the default CAR/engineered-cell scope. Response state and therapy status are stored separately; confirmed duplicates are collapsed and residual overlap remains flagged.

Audit status: registry rebuilt and safety/operations layer verified 2026-09-02. Adjacent non-CAR T-cell engagers remain available as an opt-in modality and excluded by default.

153individually attributable records; residual overlap possible in 8
1 / 109had exact patient-level CRS grade ≥3; unknown grades are excluded
11 momedian follow-up among 118 records that report it
206
literature records shown
153
individually attributable
53
confirmed re-reports shown
11 mo
median FU (n=118)
1/109
CRS grade ≥3 / exact grades
8
possible-overlap flags
Showing canonical records plus 53 confirmed re-reports/duplicates. Aggregate placeholders remain excluded.
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Disease
Outcome
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Outcomes by publication year

Hatched = re-reports of patients already counted. Watch 2021–22 (only re-reports) and the hatched tops disappear when you collapse them. Bars normalised to 100%.

02550751002021n=12022n=52023n=112024n=422025n=752026n=72
Off-therapy remission / major responseRemission, on RxResponse (not formal remission)Partial responseNo responseToo early / NRre-report
Show data table (accessible view)
SourceYearPMID(s)DiseaseModalityTargetResponse stateTherapy statusDisplay bucketFUCRSRecord status
Mougiakakos et al.2021PMID 34347960SLE (WHO class IIIA lupus nephritis with nephrotic syndrome;Autologous CAR-TCD19Source-defined remissionOff therapyOff-therapy remission / major response1.50Prior re-report / subsumed record
Mackensen et al.2022PMID 36109639SLEAutologous CAR-TCD19Source-defined remissionOff therapyOff-therapy remission / major response17NRPrior re-report / subsumed record
Mackensen et al.2022PMID 36109639SLEAutologous CAR-TCD19Source-defined remissionOff therapyOff-therapy remission / major responseNRPrior re-report / subsumed record
Mackensen et al.2022PMID 36109639SLEAutologous CAR-TCD19Source-defined remissionOff therapyOff-therapy remission / major responseNRPrior re-report / subsumed record
Mackensen et al.2022PMID 36109639SLEAutologous CAR-TCD19Source-defined remissionOff therapyOff-therapy remission / major responseNRPrior re-report / subsumed record
Mackensen et al.2022PMID 36109639SLEAutologous CAR-TCD19Source-defined remissionOff therapyOff-therapy remission / major responseNRPrior re-report / subsumed record
Pecher et al.2023PMID 37367976Antisynthetase syndrome (anti-Jo-1+) with myositis and ILD, Autologous CAR-TCD19Source-defined remissionOn therapyRemission, on Rx81Individually attributable record
Müller et al.2023PMID 36930673Anti-Jo1 antisynthetase syndrome with myositis and interstitAutologous CAR-TCD19Source-defined remissionOn therapyRemission, on Rx81Prior re-report / subsumed record
Sheng et al.2023PMID 38173731Sjogren's disease (with concurrent DLBCL)Autologous CAR-TCD19Disease-specific major/good responseOff therapyResponse (not formal remission)82Individually attributable record
Nunez et al.2023PMID 37744005SLE (refractory)Autologous CAR-TCD19Source-defined remissionOff therapyOff-therapy remission / major response3NRPrior re-report / subsumed record
Nunez et al.2023PMID 37744005SLE (refractory)Autologous CAR-TCD19Source-defined remissionOff therapyOff-therapy remission / major response3NRPrior re-report / subsumed record
Nunez et al.2023PMID 37744005SLE (refractory)Autologous CAR-TCD19Source-defined remissionOff therapyOff-therapy remission / major response3NRPrior re-report / subsumed record
Nunez et al.2023PMID 37744005SLE (refractory)Autologous CAR-TCD19Source-defined remissionOff therapyOff-therapy remission / major response3NRPrior re-report / subsumed record
Nunez et al.2023PMID 37744005SLE (refractory)Autologous CAR-TCD19Source-defined remissionOff therapyOff-therapy remission / major response3NRPrior re-report / subsumed record
Nunez et al.2023PMID 37744005SLE (refractory)Autologous CAR-TCD19Source-defined remissionOff therapyOff-therapy remission / major response3NRPrior re-report / subsumed record
Pecher et al. (target seed labeled "Müller")2023PMID 37367976Antisynthetase syndrome (anti-Jo-1; myositis + interstitial Autologous CAR-TCD19Source-defined remissionOn therapyRemission, on Rx81Confirmed duplicate / overlap
Bergmann et al.2023PMID 37147112Diffuse cutaneous SSc (anti-RNA polymerase III / RP11+), witAutologous CAR-TCD19Disease-specific major/good responseOff therapyResponse (not formal remission)61Prior re-report / subsumed record
Müller, Taubmann, Mackensen, Schett, et al.2024PMID 38381673SLEAutologous CAR-TCD19Source-defined remissionOff therapyOff-therapy remission / major response290Individually attributable record
Müller, Taubmann, Mackensen, Schett, et al.2024PMID 38381673SLEAutologous CAR-TCD19Source-defined remissionOff therapyOff-therapy remission / major response251Individually attributable record
Müller, Taubmann, Mackensen, Schett, et al.2024PMID 38381673SLEAutologous CAR-TCD19Source-defined remissionOff therapyOff-therapy remission / major response211Individually attributable record
Müller, Taubmann, Mackensen, Schett, et al.2024PMID 38381673SLEAutologous CAR-TCD19Source-defined remissionOff therapyOff-therapy remission / major response191Individually attributable record
Müller, Taubmann, Mackensen, Schett, et al.2024PMID 38381673SLEAutologous CAR-TCD19Source-defined remissionOff therapyOff-therapy remission / major response150Individually attributable record
Müller, Taubmann, Mackensen, Schett, et al.2024PMID 38381673SLEAutologous CAR-TCD19Source-defined remissionOff therapyOff-therapy remission / major response151Individually attributable record
Müller, Taubmann, Mackensen, Schett, et al.2024PMID 38381673SLEAutologous CAR-TCD19Source-defined remissionOff therapyOff-therapy remission / major response120Individually attributable record
Müller, Taubmann, Mackensen, Schett, et al.2024PMID 38381673SLEAutologous CAR-TCD19Source-defined remissionOff therapyOff-therapy remission / major response61Individually attributable record
Müller, Taubmann, Mackensen, Schett, et al.2024PMID 38381673Idiopathic inflammatory myositis (antisynthetase, Jo-1)Autologous CAR-TCD19Source-defined remissionOff therapyOff-therapy remission / major response181Individually attributable record
Müller, Taubmann, Mackensen, Schett, et al.2024PMID 38381673Idiopathic inflammatory myositis (antisynthetase, Jo-1/Pm-ScAutologous CAR-TCD19Source-defined remissionOff therapyOff-therapy remission / major response181Individually attributable record
Müller, Taubmann, Mackensen, Schett, et al.2024PMID 38381673Idiopathic inflammatory myositis (antisynthetase, PL-7)Autologous CAR-TCD19Source-defined remissionOff therapyOff-therapy remission / major response52Individually attributable record
Müller, Taubmann, Mackensen, Schett, et al.2024PMID 38381673Systemic sclerosis (RNAP III)Autologous CAR-TCD19Disease-specific major/good responseOff therapyResponse (not formal remission)131Individually attributable record
Müller, Taubmann, Mackensen, Schett, et al.2024PMID 38381673Systemic sclerosis (Scl70)Autologous CAR-TCD19Disease-specific major/good responseOff therapyResponse (not formal remission)101Individually attributable record
Müller, Taubmann, Mackensen, Schett, et al.2024PMID 38381673Systemic sclerosis (Scl70)Autologous CAR-TCD19Disease-specific major/good responseOff therapyResponse (not formal remission)71Individually attributable record
Müller, Taubmann, Mackensen, Schett, et al.2024PMID 38381673Systemic sclerosis (Scl70)Autologous CAR-TCD19Disease-specific major/good responseOff therapyResponse (not formal remission)40Individually attributable record
Wang et al.2024PMID 38777376
PMID 41612420
SLE + comorbid DLBCLAutologous CAR-TCD19/BCMASource-defined remissionOff therapyOff-therapy remission / major response67NRIndividually attributable record
Wang et al.2024PMID 38777376
PMID 41612420
SLE + comorbid DLBCLAutologous CAR-TCD19/BCMASource-defined remissionOff therapyOff-therapy remission / major response67NRIndividually attributable record
Wang et al.2024PMID 38777376
PMID 41612420
Lupus nephritis IV-G(A/C)+VAutologous CAR-TCD19/BCMASource-defined remissionOff therapyOff-therapy remission / major response33NRIndividually attributable record
Wang et al.2024PMID 38777376
PMID 41612420
Lupus nephritis class VAutologous CAR-TCD19/BCMASource-defined remissionOff therapyOff-therapy remission / major response30NRIndividually attributable record
Wang et al.2024PMID 38777376
PMID 41612420
Lupus nephritis IV-G(A/C)Autologous CAR-TCD19/BCMASource-defined remissionOff therapyOff-therapy remission / major response30NRIndividually attributable record
Wang et al.2024PMID 38777376
PMID 41612420
Lupus nephritis IV-G(A/C)+VAutologous CAR-TCD19/BCMADisease-specific major/good responseOff therapyResponse (not formal remission)30NRIndividually attributable record
Wang et al.2024PMID 38777376
PMID 41612420
Lupus nephritis IV-G(A/C)+VAutologous CAR-TCD19/BCMASource-defined remissionOff therapyOff-therapy remission / major response30NRIndividually attributable record
Wang et al.2024PMID 38777376
PMID 41612420
Lupus nephritis IV-G(A/C)Autologous CAR-TCD19/BCMASource-defined remissionOff therapyOff-therapy remission / major response24NRIndividually attributable record
Wang et al.2024PMID 38777376
PMID 41612420
SLE / lupus nephritisAutologous CAR-TCD19/BCMASource-defined remissionOff therapyOff-therapy remission / major response24NRIndividually attributable record
Wang et al.2024PMID 38777376
PMID 41612420
Lupus nephritis IV-G(A/C)+VAutologous CAR-TCD19/BCMASource-defined remissionOff therapyOff-therapy remission / major response24NRIndividually attributable record
Wang et al.2024PMID 38777376SLE / lupus nephritisAutologous CAR-TCD19/BCMAToo early / not reportedUnknownToo early / NRNRIndividually attributable record
Wang et al.2024PMID 38777376
PMID 41612420
Lupus nephritis IV-G(A/C)Autologous CAR-TCD19/BCMASource-defined remissionOff therapyOff-therapy remission / major response24NRIndividually attributable record
Wang et al.2024PMID 38777376
PMID 41612420
Lupus nephritis class III(A/C)Autologous CAR-TCD19/BCMASource-defined remissionOn therapyRemission, on Rx24NRIndividually attributable record
Nicolai et al.2024PMID 38924652Juvenile dermatomyositis (JDM), severe chronically active, rAutologous CAR-TCD19Disease-specific major/good responseOff therapyResponse (not formal remission)81Confirmed duplicate / overlap
Wang et al.2024PMID 39013470Immune-mediated necrotizing myopathy (IMNM)Allogeneic / universal CAR-TCD19Disease-specific major/good responseUnknownResponse (not formal remission)60Individually attributable record
Wang et al.2024PMID 39013470Diffuse cutaneous systemic sclerosis (dcSSc)Allogeneic / universal CAR-TCD19Disease-specific major/good responseUnknownResponse (not formal remission)60Individually attributable record
Wang et al.2024PMID 39013470Diffuse cutaneous systemic sclerosis (dcSSc)Allogeneic / universal CAR-TCD19Disease-specific major/good responseUnknownResponse (not formal remission)60Individually attributable record
Volkov et al.2024PMID 39245937Anti-SRP immune-mediated necrotizing myopathy (IMNM); 33-yeaAutologous CAR-TCD19Disease-specific major/good responseOff therapyResponse (not formal remission)40Individually attributable record
Merkt et al.2024PMID 38135464
PMID 39673062
Scl70+ systemic sclerosis with progressive NSIP/pulmonary fiAutologous CAR-TCD19Disease-specific major/good responseUnknownResponse (not formal remission)111Individually attributable record
Claus et al.2024PMID 39673062Scl70+ diffuse cutaneous systemic sclerosis with progressingAutologous CAR-TCD19Disease-specific major/good responseUnknownResponse (not formal remission)18NRConfirmed duplicate / overlap
Szabo et al.2024PMID 39448205Rheumatoid arthritis (D2T-RA, seropositive ACPA+/RF++), assoAutologous CAR-TCD20/CD19Source-defined remissionOff therapyOff-therapy remission / major response121Individually attributable record
Qin et al.2024PMID 38289960Anti-SRP IMNM (7-y refractory) with concomitant Sjogren syndAutologous CAR-TBCMASource-defined remissionOff therapyOff-therapy remission / major response181Individually attributable record
Krickau et al.2024PMID 38642568SLE with rapidly progressive, dialysis-dependent lupus nephrAutologous CAR-TCD19Source-defined remissionOff therapyOff-therapy remission / major response60Confirmed duplicate / overlap
Wang et al.2024PMID 39690781SLE with lupus nephritis (class IV-G(A/C))Autologous CAR-TCD19/BCMASource-defined remissionOff therapyOff-therapy remission / major response241Individually attributable record · Possible unresolved overlap
Friedberg et al.2024PMID 39393780SLE with triple-positive antiphospholipid syndrome (recurrenAutologous CAR-TCD19Disease-specific major/good responseUnknownResponse (not formal remission)1Individually attributable record
Li, Zhang, Jiang, et al.2024PMID 39047248SLE-associated immune thrombocytopenia (ITP), refractory; SLAutologous CAR-TCD19Source-defined remissionOn therapyRemission, on Rx61Individually attributable record
Hagen, Müller, ... Mackensen, Schett2024PMID 39615991CNS SLE — transverse myelitis with spastic paraplegia, plus Autologous CAR-TCD19Source-defined remissionOff therapyOff-therapy remission / major response30Individually attributable record · Possible unresolved overlap
Hagen M, et al. (Lancet Rheumatol)2025PMID 40318690Systemic lupus erythematosus (active lupus nephritis)Autologous CAR-TCD19Too early / not reportedUnknownToo early / NRNRPrior re-report / subsumed record
Hagen M, et al. (Lancet Rheumatol)2025PMID 40318690Systemic sclerosis (prior myocardial involvement)Autologous CAR-TCD19Too early / not reportedUnknownToo early / NRNRPrior re-report / subsumed record
Hagen M, et al. (Lancet Rheumatol)2025PMID 40318690Systemic sclerosis (prior myocardial involvement)Autologous CAR-TCD19Too early / not reportedUnknownToo early / NRNRPrior re-report / subsumed record
Hagen M, et al. (Lancet Rheumatol)2025PMID 40318690Idiopathic inflammatory myopathy (interstitial lung disease)Autologous CAR-TCD19Too early / not reportedUnknownToo early / NRNRPrior re-report / subsumed record
Hagen M, et al. (Lancet Rheumatol)2025PMID 40318690Systemic lupus erythematosus (interstitial lung disease)Autologous CAR-TCD19Too early / not reportedUnknownToo early / NRNRPrior re-report / subsumed record
Hagen M, et al. (Lancet Rheumatol)2025PMID 40318690Systemic sclerosis (interstitial lung disease)Autologous CAR-TCD19Too early / not reportedUnknownToo early / NRNRPrior re-report / subsumed record
Wang et al.2025PMID 40549291SLE overlap syndrome with Class III lupus nephritis (10-yearAutologous CAR-TCD19/BCMASource-defined remissionOff therapyOff-therapy remission / major response181Prior re-report / subsumed record
Müller et al.2025PMID 40245922Anti-Jo-1 antisynthetase syndrome / IIM with severe progressAutologous CAR-TCD19/BCMASource-defined remissionOff therapyOff-therapy remission / major response91Prior re-report / subsumed record
Haase et al.2025PMID 40268741Antisynthetase syndrome (anti-Jo1), refractory incl. daratumAutologous CAR-TCD19Source-defined remissionOn therapyRemission, on Rx62Individually attributable record
Wang et al.2025PMID 40562027Diffuse cutaneous systemic sclerosis (severe, dcSSc)CAR-NKCD19/BCMADisease-specific major/good responseUnknownResponse (not formal remission)60Individually attributable record
Albach et al.2025PMID 39928370Overlap: diffuse SSc (Scl-70+) + ACPA+ RAAutologous CAR-TCD19Source-defined remissionOff therapyOff-therapy remission / major response62Individually attributable record
París-Muñoz et al.2025PMID 40306284Anti-MDA5 dermatomyositis (juvenile DM) with rapidly progresAutologous CAR-TCD19Source-defined remissionOff therapyOff-therapy remission / major response110Prior re-report / subsumed record
Minopoulou et al.2025PMID 39893102PR3-ANCA+ granulomatosis with polyangiitis (GPA), multi-orgaAutologous CAR-TCD19Source-defined remissionOn therapyRemission, on Rx4.31Prior re-report / subsumed record
Lodka & Schreiber2025PMID 41393856PR3-ANCA GPA (refractory; lung, kidney, joints, skin, sinonaAutologous CAR-TCD19Source-defined remissionOff therapyOff-therapy remission / major response4.31Individually attributable record
Lodka & Schreiber2025PMID 41393856PR3-ANCA GPA (refractory pulmonary disease)Autologous CAR-TCD19Source-defined remissionOn therapyRemission, on Rx9.90Individually attributable record
Lodka & Schreiber2025PMID 41393856MPO-ANCA AAV (crescentic glomerulonephritis, kidney involvemAutologous CAR-TCD19Source-defined remissionOn therapyRemission, on Rx1.4NRIndividually attributable record
Wang et al.2025PMID 40446794SLE (refractory, severe, multi-organ)Allogeneic / universal CAR-TCD19Disease-specific major/good responseOn therapyResponse (not formal remission)120Individually attributable record
Wang et al.2025PMID 40446794SLE (refractory, severe, multi-organ)Allogeneic / universal CAR-TCD19Source-defined remissionOff therapyOff-therapy remission / major response120Individually attributable record
Wang et al.2025PMID 40446794SLE (refractory, severe, multi-organ)Allogeneic / universal CAR-TCD19Disease-specific major/good responseOn low-dose glucocorticoidResponse (not formal remission)120Individually attributable record
Yang et al.2025PMID 40341741SLE (prior lupus cerebritis 2018; no active CNS lupus at enrAllogeneic / universal CAR-TCD19Source-defined remissionOff therapyOff-therapy remission / major response61Individually attributable record
Yang et al.2025PMID 40341741SLE (prior lupus cerebritis 2019; no active CNS lupus at enrAllogeneic / universal CAR-TCD19Source-defined remissionOn therapyRemission, on Rx61Individually attributable record
Yang et al.2025PMID 40341741SLE (prior lupus cerebritis 2021; no active CNS lupus at enrAllogeneic / universal CAR-TCD19Source-defined remissionOn therapyRemission, on Rx61Individually attributable record
Yang et al.2025PMID 40341741SLE (refractory; prior telitacicept)Allogeneic / universal CAR-TCD19Source-defined remissionOn therapyRemission, on Rx61Individually attributable record
Taubmann et al.2025PMID 40906188SLE (class IV lupus nephritis; severe multi-organ: vasculitiAutologous CAR-TCD19Source-defined remissionOff therapyOff-therapy remission / major responseNRPrior re-report / subsumed record
Liu et al.2025PMID 40918126SLE + lupus nephritis + antiphospholipid syndrome + type B iAutologous CAR-TCD19Source-defined remissionOn therapyRemission, on Rx40Individually attributable record
Wang X, Zhang Y, et al. (Xu H, corresponding)2025PMID 40866583SLE with lupus nephritis (ISN/RPS class IV+V)STAR-T / other engineered T-cellCD19Source-defined remissionOff therapyOff-therapy remission / major response91Individually attributable record · Possible unresolved overlap
Wang X, Zhang Y, et al. (Xu H, corresponding)2025PMID 40866583SLE with lupus nephritis (ISN/RPS class III+V)STAR-T / other engineered T-cellCD19Source-defined remissionOff therapyOff-therapy remission / major response60Individually attributable record · Possible unresolved overlap
Wang X, Zhang Y, et al. (Xu H, corresponding)2025PMID 40866583SLE with lupus nephritis (ISN/RPS class III+V)STAR-T / other engineered T-cellCD19Source-defined remissionOff therapyOff-therapy remission / major response61Individually attributable record · Possible unresolved overlap
Wang X, Zhang Y, et al. (Xu H, corresponding)2025PMID 40866583SLE with lupus nephritis (ISN/RPS class IV+V)STAR-T / other engineered T-cellCD19Partial responseOff therapyPartial response60Individually attributable record · Possible unresolved overlap
Wang X, Zhang Y, et al. (Xu H, corresponding)2025PMID 40866583SLE with lupus nephritis (ISN/RPS class IV+V)STAR-T / other engineered T-cellCD19Source-defined remissionOff therapyOff-therapy remission / major response60Individually attributable record · Possible unresolved overlap
Gao J, Li M, Sun M, et al. (Zhao/Yang, Changhai Hospital, Shanghai)2025PMID 41240964SLE with lupus nephritis (proteinuria, hematuria)CAR-NKCD19Source-defined remissionOn therapyRemission, on Rx180Individually attributable record
Gao J, Li M, Sun M, et al. (Zhao/Yang, Changhai Hospital, Shanghai)2025PMID 41240964SLE (hematologic/bone-marrow, joints)CAR-NKCD19Source-defined remissionOn therapyRemission, on Rx150Individually attributable record
Gao J, Li M, Sun M, et al. (Zhao/Yang, Changhai Hospital, Shanghai)2025PMID 41240964SLE with renal involvement (pyuria), MALECAR-NKCD19Source-defined remissionOn therapyRemission, on Rx150Individually attributable record
Gao J, Li M, Sun M, et al. (Zhao/Yang, Changhai Hospital, Shanghai)2025PMID 41240964SLE (skin, bone-marrow, joints)CAR-NKCD19Source-defined remissionOn therapyRemission, on Rx120Individually attributable record
Gao J, Li M, Sun M, et al. (Zhao/Yang, Changhai Hospital, Shanghai)2025PMID 41240964SLE with lupus nephritis (proteinuria, hematuria, pyuria, vaCAR-NKCD19Disease-specific major/good responseUnknownResponse (not formal remission)120Individually attributable record
Gao J, Li M, Sun M, et al. (Zhao/Yang, Changhai Hospital, Shanghai)2025PMID 41240964SLE with lupus nephritis (pyuria, bone-marrow, joints)CAR-NKCD19Source-defined remissionOn therapyRemission, on Rx120Individually attributable record
Gao J, Li M, Sun M, et al. (Zhao/Yang, Changhai Hospital, Shanghai)2025PMID 41240964SLE with lupus nephritis (proteinuria, hematuria, bone-marroCAR-NKCD19Source-defined remissionOn therapyRemission, on Rx121Individually attributable record
Gao J, Li M, Sun M, et al. (Zhao/Yang, Changhai Hospital, Shanghai)2025PMID 41240964SLE (hematologic — chronic thrombocytopenia, joints)CAR-NKCD19Disease-specific major/good responseUnknownResponse (not formal remission)120Individually attributable record
Gao J, Li M, Sun M, et al. (Zhao/Yang, Changhai Hospital, Shanghai)2025PMID 41240964SLE with lupus nephritis (pyuria, skin, joints)CAR-NKCD19Disease-specific major/good responseUnknownResponse (not formal remission)120Individually attributable record
Gao J, Li M, Sun M, et al. (Zhao/Yang, Changhai Hospital, Shanghai)2025PMID 41240964SLE (skin, bone-marrow)CAR-NKCD19Source-defined remissionOn therapyRemission, on Rx110Individually attributable record
Gao J, Li M, Sun M, et al. (Zhao/Yang, Changhai Hospital, Shanghai)2025PMID 41240964SLE (vascular)CAR-NKCD19Source-defined remissionOn therapyRemission, on Rx110Individually attributable record
Gao J, Li M, Sun M, et al. (Zhao/Yang, Changhai Hospital, Shanghai)2025PMID 41240964SLE (skin, joints)CAR-NKCD19Source-defined remissionOn therapyRemission, on Rx110Individually attributable record
Gao J, Li M, Sun M, et al. (Zhao/Yang, Changhai Hospital, Shanghai)2025PMID 41240964SLE (bone-marrow, joints)CAR-NKCD19Source-defined remissionOn therapyRemission, on Rx90Individually attributable record
Gao J, Li M, Sun M, et al. (Zhao/Yang, Changhai Hospital, Shanghai)2025PMID 41240964SLE (skin, joints)CAR-NKCD19Source-defined remissionOn therapyRemission, on Rx90Individually attributable record
Gao J, Li M, Sun M, et al. (Zhao/Yang, Changhai Hospital, Shanghai)2025PMID 41240964SLE (skin, joints)CAR-NKCD19Disease-specific major/good responseUnknownResponse (not formal remission)70Individually attributable record
Gao J, Li M, Sun M, et al. (Zhao/Yang, Changhai Hospital, Shanghai)2025PMID 41240964SLE with lupus nephritis (proteinuria, pyuria)CAR-NKCD19Source-defined remissionOn therapyRemission, on Rx70Individually attributable record
Gao J, Li M, Sun M, et al. (Zhao/Yang, Changhai Hospital, Shanghai)2025PMID 41240964SLE (joints)CAR-NKCD19Source-defined remissionOn therapyRemission, on Rx70Individually attributable record
Gao J, Li M, Sun M, et al. (Zhao/Yang, Changhai Hospital, Shanghai)2025PMID 41240964SLE with lupus nephritis (proteinuria)CAR-NKCD19Partial responseUnknownPartial response50Individually attributable record
Feng, Huo, Hong, et al. (Hu/Huang)2025PMID 40993243SLE with lupus nephritis (class V), skin and joint involvemeAutologous CAR-TCD19/BCMASource-defined remissionOff therapyOff-therapy remission / major response1Individually attributable record
Feng, Huo, Hong, et al. (Hu/Huang)2025PMID 40993243SLE with lupus nephritis (class IV), skin and joint involvemAutologous CAR-TCD19/BCMAPartial responseUnknownPartial response1Individually attributable record
Feng, Huo, Hong, et al. (Hu/Huang)2025PMID 40993243SLE with lupus nephritis (class III+V), U1-RNP/Ro52/histone Autologous CAR-TCD19/BCMADisease-specific major/good responseOff therapyResponse (not formal remission)1Individually attributable record
Feng, Huo, Hong, et al. (Hu/Huang)2025PMID 40993243SLE with lupus nephritis (class IV), skin involvementAutologous CAR-TCD19/BCMASource-defined remissionOff therapyOff-therapy remission / major response1Individually attributable record
Feng, Huo, Hong, et al. (Hu/Huang)2025PMID 40993243SLE (male) with lupus nephritis (class IV), joint and lung iAutologous CAR-TCD19/BCMASource-defined remissionOff therapyOff-therapy remission / major response1Individually attributable record
Feng, Huo, Hong, et al. (Hu/Huang)2025PMID 40993243SLE, skin and joint involvement (no nephritis)Autologous CAR-TCD19/BCMASource-defined remissionOff therapyOff-therapy remission / major response1Individually attributable record
Feng, Huo, Hong, et al. (Hu/Huang)2025PMID 40993243SLE, joint involvement (no nephritis)Autologous CAR-TCD19/BCMASource-defined remissionOff therapyOff-therapy remission / major response1Individually attributable record
Feng, Huo, Hong, et al. (Hu/Huang)2025PMID 40993243SLE with lupus nephritis (class IV), skin involvementAutologous CAR-TCD19/BCMASource-defined remissionOff therapyOff-therapy remission / major response1Individually attributable record
Feng, Huo, Hong, et al. (Hu/Huang)2025PMID 40993243SLE with lupus nephritis (class IV), skin and joint involvemAutologous CAR-TCD19/BCMASource-defined remissionOff therapyOff-therapy remission / major response1Individually attributable record
Feng, Huo, Hong, et al. (Hu/Huang)2025PMID 40993243SLE with lupus nephritis (class IV), skin and joint involvemAutologous CAR-TCD19/BCMASource-defined remissionOff therapyOff-therapy remission / major response1Individually attributable record
Feng, Huo, Hong, et al. (Hu/Huang)2025PMID 40993243SLE with myositis, skin and joint involvement (no nephritis)Autologous CAR-TCD19/BCMASource-defined remissionOff therapyOff-therapy remission / major response1Individually attributable record
Feng, Huo, Hong, et al. (Hu/Huang)2025PMID 40993243SLE with lupus nephritis (class IV), skin and joint involvemAutologous CAR-TCD19/BCMASource-defined remissionOff therapyOff-therapy remission / major response1Individually attributable record
Feng, Huo, Hong, et al. (Hu/Huang)2025PMID 40993243SLE with lupus nephritis (class V), skin and joint involvemeAutologous CAR-TCD19/BCMASource-defined remissionOff therapyOff-therapy remission / major response1Individually attributable record
Feng, Huo, Hong, et al. (Hu/Huang)2025PMID 40993243SLE with lupus nephritis (class III), skin/joint/lung involvAutologous CAR-TCD19/BCMADisease-specific major/good responseOff therapyResponse (not formal remission)1Individually attributable record
Feng, Huo, Hong, et al. (Hu/Huang)2025PMID 40993243SLE, skin and joint involvement (no nephritis)Autologous CAR-TCD19/BCMASource-defined remissionOff therapyOff-therapy remission / major response1Individually attributable record
He et al.2025PMID 39561867Refractory pediatric SLE (>3 yr; rashes, ulcers, arthritis, Autologous CAR-TCD19Source-defined remissionOff therapyOff-therapy remission / major response51Individually attributable record
He et al.2025PMID 39561867Pediatric SLE (>5 yr) with Class IV lupus nephritis (baselinAutologous CAR-TCD19Disease-specific major/good responseOff therapyResponse (not formal remission)41Individually attributable record
Hu Z, Cai S, et al. (Dong L, senior)2025PMID 40681435Lupus nephritis, ISN/RPS class IV (SLE)Autologous CAR-TBCMASource-defined remissionOff therapyOff-therapy remission / major response120Individually attributable record
Hu Z, Cai S, et al. (Dong L, senior)2025PMID 40681435Lupus nephritis, ISN/RPS class III+V (SLE)Autologous CAR-TBCMASource-defined remissionOff therapyOff-therapy remission / major response120Individually attributable record
Hu Z, Cai S, et al. (Dong L, senior)2025PMID 40681435Lupus nephritis, ISN/RPS class IV (SLE)Autologous CAR-TBCMADisease-specific major/good responseOff therapyResponse (not formal remission)90Individually attributable record
Hu Z, Cai S, et al. (Dong L, senior)2025PMID 40681435Lupus nephritis, ISN/RPS class III (SLE)Autologous CAR-TBCMASource-defined remissionOff therapyOff-therapy remission / major response90Individually attributable record
Hu Z, Cai S, et al. (Dong L, senior)2025PMID 40681435Lupus nephritis, ISN/RPS class IV+V (SLE)Autologous CAR-TBCMASource-defined remissionOff therapyOff-therapy remission / major response90Individually attributable record
Hu Z, Cai S, et al. (Dong L, senior)2025PMID 40681435Lupus nephritis, ISN/RPS class IV (SLE)Autologous CAR-TBCMASource-defined remissionOff therapyOff-therapy remission / major response91Individually attributable record
Hu Z, Cai S, et al. (Dong L, senior)2025PMID 40681435Lupus nephritis, ISN/RPS class IV (SLE)Autologous CAR-TBCMADisease-specific major/good responseOff therapyResponse (not formal remission)60Individually attributable record
Cai et al.2025PMID 41109316IgG4-related disease (biopsy-proven, multiorgan; right lacriAutologous CAR-TBCMASource-defined remissionOff therapyOff-therapy remission / major response90Individually attributable record
Cai et al.2025PMID 41109316IgG4-related disease (biopsy-proven, multiorgan; left parotiAutologous CAR-TBCMASource-defined remissionOff therapyOff-therapy remission / major response90Individually attributable record
Keitel et al.2025PMID 41371348Multiorgan IgG4-RD (pancreas, hepatobiliary tract, lungs), tAutologous CAR-TCD19Source-defined remissionOff therapyOff-therapy remission / major response121Individually attributable record
Garantziotis et al.2026PMID 40701862Systemic lupus erythematosus (treatment-refractory)Autologous CAR-TCD19Source-defined remissionOff therapyOff-therapy remission / major responseNRPrior re-report / subsumed record
Garantziotis et al.2026PMID 40701862Systemic lupus erythematosus (treatment-refractory)Autologous CAR-TCD19Source-defined remissionOff therapyOff-therapy remission / major responseNRPrior re-report / subsumed record
Garantziotis et al.2026PMID 40701862Systemic lupus erythematosus (treatment-refractory)Autologous CAR-TCD19Source-defined remissionOff therapyOff-therapy remission / major responseNRPrior re-report / subsumed record
Garantziotis et al.2026PMID 40701862Systemic lupus erythematosus (treatment-refractory)Autologous CAR-TCD19Source-defined remissionOff therapyOff-therapy remission / major responseNRPrior re-report / subsumed record
Garantziotis et al.2026PMID 40701862Systemic lupus erythematosus (treatment-refractory)Autologous CAR-TCD19Source-defined remissionOff therapyOff-therapy remission / major responseNRPrior re-report / subsumed record
Garantziotis et al.2026PMID 40701862Systemic lupus erythematosus (treatment-refractory)Autologous CAR-TCD19Source-defined remissionOff therapyOff-therapy remission / major responseNRPrior re-report / subsumed record
Garantziotis et al.2026PMID 40701862Systemic lupus erythematosus (treatment-refractory)Autologous CAR-TCD19Source-defined remissionOff therapyOff-therapy remission / major responseNRPrior re-report / subsumed record
Becilli, Metzler, Bracaglia, et al. (Locatelli/De Benedetti/Schett senior)2026PMID 41644747Childhood-onset SLE (class II/V lupus nephritis, ILD + PAH, Autologous CAR-TCD19Source-defined remissionOff therapyOff-therapy remission / major response24NRIndividually attributable record
Becilli, Metzler, Bracaglia, et al. (Locatelli/De Benedetti/Schett senior)2026PMID 41644747Juvenile dermatomyositis (calcinosis universalis; male, age Autologous CAR-TCD19Source-defined remissionOff therapyOff-therapy remission / major response241Individually attributable record
Becilli, Metzler, Bracaglia, et al. (Locatelli/De Benedetti/Schett senior)2026PMID 41644747Childhood-onset SLE (class IV/V LN, ILD + diffuse alveolar hAutologous CAR-TCD19Source-defined remissionOff therapyOff-therapy remission / major response18NRIndividually attributable record
Becilli, Metzler, Bracaglia, et al. (Locatelli/De Benedetti/Schett senior)2026PMID 41644747Juvenile dermatomyositis (calcinosis universalis, NXP2 histoAutologous CAR-TCD19Disease-specific major/good responseOff therapyResponse (not formal remission)121Individually attributable record
Becilli, Metzler, Bracaglia, et al. (Locatelli/De Benedetti/Schett senior)2026PMID 41644747Juvenile dermatomyositis with ILD (age 5; mosaic trisomy 21/Autologous CAR-TCD19Disease-specific major/good responseOff therapyResponse (not formal remission)9NRIndividually attributable record
Becilli, Metzler, Bracaglia, et al. (Locatelli/De Benedetti/Schett senior)2026PMID 41644747Childhood-onset SLE, dialysis-dependent AKI (class IV LN, heAutologous CAR-TCD19Disease-specific major/good responseOff therapyResponse (not formal remission)241Individually attributable record
Becilli, Metzler, Bracaglia, et al. (Locatelli/De Benedetti/Schett senior)2026PMID 41644747Childhood-onset SLE (class IV/V LN, hematologic, serositis; Autologous CAR-TCD19Source-defined remissionOff therapyOff-therapy remission / major response12NRIndividually attributable record
Becilli, Metzler, Bracaglia, et al. (Locatelli/De Benedetti/Schett senior)2026PMID 41644747Juvenile systemic sclerosis (SCL-70/SSA/Ku positive, historiAutologous CAR-TCD19Disease-specific major/good responseOff therapyResponse (not formal remission)12NRIndividually attributable record
Yang L, Wan X, et al. (Li BS senior author)2026PMID 41852345Post-HSCT warm AIHA with concurrent bone-marrow B-ALL relapsAutologous CAR-TCD19/CD22Source-defined remissionOff therapyOff-therapy remission / major response39.30Individually attributable record
Yang L, Wan X, et al. (Li BS senior author)2026PMID 41852345Post-HSCT warm AIHA (steroid/IVIG/bortezomib-refractory) witAutologous CAR-TCD19/CD22Source-defined remissionOff therapyOff-therapy remission / major response36.51Individually attributable record
Yang L, Wan X, et al. (Li BS senior author)2026PMID 41852345Isolated refractory post-HSCT warm AIHA (no leukemia relapseAutologous CAR-TCD19/CD22Source-defined remissionOff therapyOff-therapy remission / major response9.61Individually attributable record
Rimar et al.2026PMID 41936079SCL-70-positive SSc (labeled limited cutaneous in text), NSIAutologous CAR-TCD19Disease-specific major/good responseUnknownResponse (not formal remission)121Individually attributable record
Rimar et al.2026PMID 41936079RNA polymerase III-positive diffuse cutaneous SSc (dcSSc), NAutologous CAR-TCD19Disease-specific major/good responseUnknownResponse (not formal remission)110Individually attributable record
Rimar et al.2026PMID 41936079RNA polymerase III-positive diffuse cutaneous SSc (dcSSc) wiAutologous CAR-TCD19No responseUnknownNo response110Individually attributable record
Jia et al.2026PMID 42223209Progressive dcSSc (anti-Scl-70+; digital ulcers, arthritis, Autologous CAR-TCD19Disease-specific major/good responseUnknownResponse (not formal remission)9NRIndividually attributable record
Jia et al.2026PMID 42223209SSc-myositis overlap (anti-fibrillarin+ and anti-Ku+; ILD, dAutologous CAR-TCD19Disease-specific major/good responseUnknownResponse (not formal remission)9NRIndividually attributable record
Jia et al.2026PMID 42223209Progressive dcSSc (anti-Scl-70+; ILD, contractures)Autologous CAR-TCD19Disease-specific major/good responseUnknownResponse (not formal remission)9NRIndividually attributable record
Jia et al.2026PMID 42223209Progressive dcSSc (anti-Scl-70+; highest mRSS, digital ulcerAutologous CAR-TCD19Disease-specific major/good responseUnknownResponse (not formal remission)9NRIndividually attributable record
Jia et al.2026PMID 42223209Progressive dcSSc (low ANA 1:80, no SSc-specific autoantibodAutologous CAR-TCD19Disease-specific major/good responseUnknownResponse (not formal remission)93Individually attributable record
Jia et al.2026PMID 42223209Progressive dcSSc (anti-fibrillarin+; ILD)Autologous CAR-TCD19Disease-specific major/good responseUnknownResponse (not formal remission)9NRIndividually attributable record
Müller et al.2026PMID 41501497SLE (lupus nephritis)Autologous CAR-TCD19Source-defined remissionOff therapyOff-therapy remission / major responseNRPrior re-report / subsumed record
Müller et al.2026PMID 41501497SScAutologous CAR-TCD19Too early / not reportedOff therapyToo early / NR2Prior re-report / subsumed record
Müller et al.2026PMID 41501497SLE (lupus nephritis)Autologous CAR-TCD19Disease-specific major/good responseOff therapyResponse (not formal remission)NRPrior re-report / subsumed record
Müller et al.2026PMID 41501497IIMAutologous CAR-TCD19Partial responseOff therapyPartial response9NRPrior re-report / subsumed record
Jiang et al.2026PMID 41669912SLE with class IV lupus nephritisAutologous CAR-TCD19/BCMASource-defined remissionOff therapyOff-therapy remission / major response301Individually attributable record · Possible unresolved overlap
Kremer et al.2026PMID 41984818Seropositive RA / SSc overlap, with interstitial lung diseasAutologous CAR-TCD19Disease-specific major/good responseUnknownResponse (not formal remission)12NRIndividually attributable record
París-Muñoz et al.2026PMID 42285038MDA5+ juvenile dermatomyositis with rapidly progressive ILD Autologous CAR-TCD19Source-defined remissionOff therapyOff-therapy remission / major response110Individually attributable record
Schneider et al.2026PMID 41834136GPA (ANCA-associated vasculitis), relapsing/refractory, lungAutologous CAR-TCD19Source-defined remissionOff therapyOff-therapy remission / major response120Individually attributable record
Korte et al.2026PMID 41962541Cold- and warm-agglutinin AIHA (refractory to 9 prior lines)Autologous CAR-TCD19Source-defined remissionOn therapyRemission, on Rx110Individually attributable record
Shan et al.2026PMID 41935952SLEAutologous CAR-TCD19Source-defined remissionOff therapyOff-therapy remission / major responseNRIndividually attributable record
Shan et al.2026PMID 41935952SLE (high baseline activity, SLEDAI 10)Autologous CAR-TCD19Source-defined remissionOff therapyOff-therapy remission / major responseNRIndividually attributable record
Shan et al.2026PMID 41935952SLE (baseline SLEDAI-2K <4, on ≥7.5 mg/day prednisolone)Autologous CAR-TCD19Source-defined remissionOff therapyOff-therapy remission / major responseNRIndividually attributable record
Shan et al.2026PMID 41935952SLE (high baseline activity, SLEDAI 10)Autologous CAR-TCD19Source-defined remissionOff therapyOff-therapy remission / major responseNRIndividually attributable record
Shan et al.2026PMID 41935952SLEAutologous CAR-TCD19Disease-specific major/good responseOff therapyResponse (not formal remission)NRIndividually attributable record
Shan et al.2026PMID 41935952SLEAutologous CAR-TCD19Source-defined remissionOff therapyOff-therapy remission / major responseNRIndividually attributable record
Shan et al.2026PMID 41935952SLEAutologous CAR-TCD19Source-defined remissionOff therapyOff-therapy remission / major responseNRIndividually attributable record
Shan et al.2026PMID 41935952SLE (baseline SLEDAI-2K <4)Autologous CAR-TCD19Source-defined remissionOff therapyOff-therapy remission / major responseNRIndividually attributable record
Shan et al.2026PMID 41935952SLE (baseline SLEDAI-2K <4)Autologous CAR-TCD19Source-defined remissionOff therapyOff-therapy remission / major responseNRIndividually attributable record
Shan et al.2026PMID 41935952SLEAutologous CAR-TCD19Source-defined remissionOff therapyOff-therapy remission / major responseNRIndividually attributable record
Shan et al.2026PMID 41935952SLEAutologous CAR-TCD19Source-defined remissionOff therapyOff-therapy remission / major responseNRIndividually attributable record
Shan et al.2026PMID 41935952SLE with lupus nephritis (grade IV-V)Autologous CAR-TCD19No responseOff therapyNo responseNRIndividually attributable record
Shan et al.2026PMID 41935952SLEAutologous CAR-TCD19Source-defined remissionOff therapyOff-therapy remission / major responseNRIndividually attributable record
Shan et al.2026PMID 41935952SLEAutologous CAR-TCD19Source-defined remissionOff therapyOff-therapy remission / major responseNRIndividually attributable record
Shan et al.2026PMID 41935952SLE with lupus nephritisAutologous CAR-TCD19No responseOff therapyNo responseNRIndividually attributable record
Shan et al.2026PMID 41935952SLEAutologous CAR-TCD19Disease-specific major/good responseOff therapyResponse (not formal remission)NRIndividually attributable record
Shan et al.2026PMID 41935952SLEAutologous CAR-TCD19Source-defined remissionOff therapyOff-therapy remission / major responseNRIndividually attributable record
Shan et al.2026PMID 41935952SLEAutologous CAR-TCD19Source-defined remissionOff therapyOff-therapy remission / major responseNRIndividually attributable record
Xu et al.2026PMID 42297600SLE (refractory)Autologous CAR-TCD19/BCMASource-defined remissionOff therapyOff-therapy remission / major response120Individually attributable record
Xu et al.2026PMID 42297600SLE (refractory)Autologous CAR-TCD19/BCMADisease-specific major/good responseUnknownResponse (not formal remission)120Individually attributable record
Xu et al.2026PMID 42297600SLE (refractory)Autologous CAR-TCD19/BCMASource-defined remissionOff therapyOff-therapy remission / major response120Individually attributable record
Zhang C-x, et al.2026PMID 42414128Paediatric SLE with refractory immune thrombocytopeniaAutologous CAR-TCD19/CD22Source-defined remissionOff therapyOff-therapy remission / major response121Individually attributable record
Pecher, Henes, Henes, ... (Schett, Hagen)2026Systemic lupus erythematosusAutologous CAR-TCD19Too early / not reportedUnknownToo early / NR12NRPrior re-report / subsumed record
Pecher, Henes, Henes, ... (Schett, Hagen)2026Systemic lupus erythematosusAutologous CAR-TCD19Too early / not reportedUnknownToo early / NR12NRPrior re-report / subsumed record
Pecher, Henes, Henes, ... (Schett, Hagen)2026Systemic lupus erythematosusAutologous CAR-TCD19Too early / not reportedUnknownToo early / NR12NRPrior re-report / subsumed record
Pecher, Henes, Henes, ... (Schett, Hagen)2026Systemic lupus erythematosusAutologous CAR-TCD19Too early / not reportedUnknownToo early / NR12NRPrior re-report / subsumed record
Pecher, Henes, Henes, ... (Schett, Hagen)2026Systemic lupus erythematosusAutologous CAR-TCD19Too early / not reportedUnknownToo early / NR12NRPrior re-report / subsumed record
Pecher, Henes, Henes, ... (Schett, Hagen)2026Systemic lupus erythematosusAutologous CAR-TCD19Too early / not reportedUnknownToo early / NR12NRPrior re-report / subsumed record
Pecher, Henes, Henes, ... (Schett, Hagen)2026Systemic lupus erythematosusAutologous CAR-TCD19Too early / not reportedUnknownToo early / NR12NRPrior re-report / subsumed record
Pecher, Henes, Henes, ... (Schett, Hagen)2026Systemic lupus erythematosusAutologous CAR-TCD19Too early / not reportedUnknownToo early / NR12NRPrior re-report / subsumed record
Pecher, Henes, Henes, ... (Schett, Hagen)2026Systemic lupus erythematosusAutologous CAR-TCD19Too early / not reportedUnknownToo early / NR12NRPrior re-report / subsumed record
Pecher, Henes, Henes, ... (Schett, Hagen)2026Systemic lupus erythematosusAutologous CAR-TCD19Too early / not reportedUnknownToo early / NR12NRPrior re-report / subsumed record
Pecher, Henes, Henes, ... (Schett, Hagen)2026Systemic lupus erythematosusAutologous CAR-TCD19Too early / not reportedUnknownToo early / NR12NRPrior re-report / subsumed record
Pecher, Henes, Henes, ... (Schett, Hagen)2026Systemic lupus erythematosusAutologous CAR-TCD19Too early / not reportedUnknownToo early / NR12NRPrior re-report / subsumed record
Pecher, Henes, Henes, ... (Schett, Hagen)2026Systemic lupus erythematosusAutologous CAR-TCD19Too early / not reportedUnknownToo early / NR12NRPrior re-report / subsumed record
Dehdashtian et al.2026PMID 41850942SLE (refractory)Autologous CAR-TCD19Disease-specific major/good responseOff therapyResponse (not formal remission)5NRIndividually attributable record
Corrected 2026-09-02. Patient tier: individually attributable records after confirmed-overlap collapse; possible overlap remains. Cohort tier: report-level enrollments with residual overlap, never unique-patient totals. Trial tier: Rebuilt from ClinicalTrials.gov on 2026-09-02: Interventional registry record with an explicit in-scope rheumatic disease in title, condition, or study description and an explicit CAR/CAAR/STAR/TCR-engineered-T or adjacent T-cell-engager intervention signal. Eligibility-only disease mentions are retained in excluded_candidates for review but are not counted; neurologic-only, hematologic-only, observational, transplant/depletion-only, and other non-engineered false positives are excluded. Adjacent non-CAR T-cell engagers are retained only as an opt-in modality. Every adverse-event rate uses an event-specific reported denominator. Safety/operations signals are source-dated and kept separate from registry status and adverse-event denominators. Hover marks for citations and audit notes.